GTF3A

Across TCGA patient cohorts, GTF3A mutation is significantly associated with the RNA expression of many other genes, with 1,735 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GTF3A-associated genes across cancer lineages are SPCS2P2, DCP1A, and TAF9. Each is linked with GTF3A in more than 1 cancer types. Because this analysis shows association rather than direction, both GTF3A-to-partner and partner-to-GTF3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPCS2P2 grouped by GTF3A-low versus GTF3A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTF3A→partner) and Y-score (partner→GTF3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SPCS2P2 →	+0.063	+2.476	<.001	.009	3	1
UCEC	DCP1A →	+0.709	+3.212	<.001	.009	3	1
UCEC	TAF9 →	+0.658	+3.459	<.001	.005	3	1
UCEC	ZNF2 →	+0.352	+2.743	.005	.003	3	1
UCEC	FRG1HP →	+0.672	+2.732	<.001	.003	3	1
UCEC	ZNF8 →	+0.669	+3.507	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,735 associations by consensus.

SPCS2P2 by GTF3A expression — UCEC

Explore this box plot interactively →