GTF3A

Across TCGA pan-cancer cohorts, GTF3A RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of GTF3A’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where GTF3A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GTF3A is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

KIRC, COAD, and BLCA are the cancer types where GTF3A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GTF3A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	IV	+1.240	<.001	12	view →
COAD	Female	III,IV	+2.268	<.001	11	view →
BLCA	All	All	+0.677	<.001	11	view →
KIRP	Male	II,III,IV	+0.980	<.001	9	view →
READ	All	II,III,IV	+1.437	<.001	7	view →
LUAD	Male	II,III,IV	+0.729	<.001	7	view →
STAD	All	II,III,IV	+0.986	<.001	6	view →
LIHC	Male	All	+0.597	<.001	6	view →
UCEC	All	All	+0.540	<.001	6	view →
BRCA	All	III,IV	+0.391	<.001	6	view →
KICH	Female	II,III,IV	−0.997	.001	4	view →
ESCA	All	All	+0.856	.003	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

GTF3A–KIRC

Open the KIRC breakdown →