GTF3A

Across TCGA pan-cancer cohorts, GTF3A RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated GTF3A data layer compared with 3 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher GTF3A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated GTF3A expression acts as an unfavorable survival marker, although some lineages such as THYM and SKCM show a favorable association.

UVM, ACC, and KICH are the cancer types where GTF3A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	II,III,IV	0.243	0.691	<.001	130	view →
ACC	DFS	Tertile	II,III,IV	0.235	0.714	.001	73	view →
KICH	OS	Median	II,III,IV	0.621	0.964	.002	60	view →
READ	DFS	Quartile	All	0.581	0.921	.001	51	view →
LIHC	OS	Tertile	III,IV	0.456	0.744	.003	49	view →
ESCA	DFS	Median	All	0.463	0.604	.019	28	view →
LGG	OS	Tertile	All	0.837	0.930	<.001	27	view →
KIRC	OS	Quartile	All	0.810	0.905	.010	24	view →
THYM	OS	Median	II,III,IV	1.000	0.889	.012	13	view →
CESC	DFS	Tertile	IV	0.326	0.760	.006	12	view →
SCLC	DFS	Tertile	II,III,IV	0.356	0.976	.006	12	view →
DLBC	DFS	Median	II,III,IV	0.358	0.918	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GTF3A–UVM (DFS)

Open the UVM breakdown →