GRK3

Across TCGA patient cohorts, GRK3 mutation is significantly associated with the RNA expression of many other genes, with 3,139 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRK3-associated genes across cancer lineages are ACTRT2, LINC00326, and KCND3-AS1. Each is linked with GRK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both GRK3-to-partner and partner-to-GRK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACTRT2 grouped by GRK3-low versus GRK3-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRK3→partner) and Y-score (partner→GRK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ACTRT2 →	+0.363	+3.420	<.001	.006	3	2
READ	LINC00326 →	+0.838	+6.006	<.001	<.001	3	2
READ	KCND3-AS1 →	+0.218	+4.653	<.001	.007	3	2
READ	SERPINA2 →	+0.098	+4.202	.004	.008	3	2
LIHC	RNU6-598P →	+0.511	+5.033	<.001	.009	3	2
LIHC	ZNF619P1 →	+0.076	+6.008	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,139 associations by consensus.

ACTRT2 by GRK3 expression — LUAD

Explore this box plot interactively →