GRK3

Across TCGA pan-cancer cohorts, GRK3 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated GRK3 data layer compared with 5 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in brain lower grade glioma (LGG), where higher GRK3 RNA is associated with better overall survival. In most high-consensus cancer types, elevated GRK3 expression acts as an unfavorable survival marker, although some lineages such as LGG and HNSC show a favorable association.

LGG, UVM, and HNSC are the cancer types where GRK3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Median	All	0.524	0.360	<.001	52	view →
UVM	OS	Quartile	III,IV	0.363	1.000	.002	51	view →
HNSC	DFS	Tertile	II,III,IV	0.696	0.533	.004	41	view →
BRCA	OS	Tertile	III,IV	0.893	0.754	.013	28	view →
LUAD	OS	Tertile	III,IV	0.817	0.609	.005	27	view →
BLCA	OS	Median	All	0.493	0.342	.008	26	view →
KIRC	DFS	Quartile	III,IV	0.967	0.703	.005	24	view →
PAAD	OS	Tertile	All	0.676	0.444	.007	21	view →
DLBC	OS	Median	II,III,IV	1.000	0.303	.013	19	view →
KICH	OS	Quartile	All	0.705	1.000	.014	15	view →
CHOL	DFS	Quartile	All	1.000	0.107	.017	15	view →
MESO	DFS	Median	II,III,IV	0.312	0.589	.024	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GRK3–LGG (OS)

Open the LGG breakdown →