GRK3

Across TCGA pan-cancer cohorts, GRK3 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of GRK3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where GRK3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GRK3 is over-expressed in tumor, although a few such as LUAD and BRCA show the opposite, repressed pattern.

HNSC, KIRC, and LIHC are the cancer types where GRK3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GRK3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+1.200	<.001	12	view →
KIRC	Male	IV	+0.827	<.001	11	view →
LIHC	All	II,III,IV	+1.149	<.001	7	view →
LUAD	Male	All	−0.733	<.001	7	view →
BRCA	All	III,IV	−1.298	<.001	6	view →
UCEC	All	All	−0.745	.003	6	view →
CHOL	All	All	+1.632	<.001	5	view →
STAD	All	II,III,IV	+0.680	.005	5	view →
LUSC	Male	All	−0.632	<.001	5	view →
THCA	All	All	−0.372	<.001	4	view →
BLCA	Female	IV	+1.779	.014	2	view →
PRAD	All	All	+0.518	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

GRK3–HNSC

Open the HNSC breakdown →