GPR68

Across TCGA cell cohorts, GPR68 mutation is significantly associated with the mutation status of many other genes, with 2,425 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GPR68-associated genes across cancer lineages are RGS3, HSF1, and WDR91. Each is linked with GPR68 in more than 3 cancer types. Because this analysis shows association rather than direction, both GPR68-to-partner and partner-to-GPR68 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RGS3 grouped by GPR68-low versus GPR68-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR68→partner) and Y-score (partner→GPR68) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RGS3 →	+3.338	+4.083	.003	.003	1	4
BLOOD_Lymphoma	HSF1 →	+6.014	+6.014	.001	.001	1	4
BLOOD_Lymphoma	WDR91 →	+5.014	+5.584	.003	.003	1	3
OVARY	ATXN1 →	+4.415	+4.977	.007	.007	1	3
OVARY	LRRC4B →	+5.415	+5.415	.004	.004	1	3
OVARY	CCDC102A →	+5.415	+5.415	.004	.004	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,425 associations by consensus.

RGS3 by GPR68 expression — BLOOD_Leukemia

Explore this box plot interactively →