GPR68

Across TCGA pan-cancer cohorts, GPR68 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated GPR68 data layer compared with 3 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher GPR68 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated GPR68 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

UVM, KIRC, and KIRP are the cancer types where GPR68 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.375	0.835	<.001	106	view →
KIRC	OS	Median	All	0.548	0.708	<.001	96	view →
KIRP	OS	Median	All	0.518	0.812	<.001	96	view →
BLCA	OS	Tertile	All	0.350	0.571	.004	37	view →
UCEC	DFS	Median	All	0.735	0.556	.004	36	view →
ACC	OS	Tertile	III,IV	0.446	0.811	.014	18	view →
MESO	OS	Tertile	All	0.221	0.447	.017	16	view →
SKCM	DFS	Median	IV	0.763	0.187	.006	14	view →
LUAD	DFS	Tertile	II,III,IV	0.519	0.274	.006	13	view →
DLBC	DFS	Quartile	All	1.000	0.377	.018	12	view →
CESC	DFS	Median	III,IV	0.464	0.780	.013	8	view →
COAD	OS	Median	III,IV	0.863	0.689	.012	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GPR68–UVM (DFS)

Open the UVM breakdown →