GPR68

Across TCGA pan-cancer cohorts, GPR68 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of GPR68’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where GPR68 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GPR68 is over-expressed in tumor.

HNSC, COAD, and BRCA are the cancer types where GPR68 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GPR68 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+1.376	<.001	10	view →
COAD	All	All	+0.463	.002	8	view →
BRCA	All	III,IV	+1.721	<.001	6	view →
STAD	Male	II,III,IV	+1.057	.002	5	view →
CHOL	All	All	+1.557	.006	2	view →
LIHC	Female	All	+0.401	.014	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

GPR68–HNSC

Open the HNSC breakdown →