GPR42

Across TCGA patient cohorts, GPR42 mutation is significantly associated with the RNA expression of many other genes, with 94 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible GPR42-associated genes across cancer lineages are SPCS2P2, MIR6853, and H2AB2. Each is linked with GPR42 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR42-to-partner and partner-to-GPR42 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPCS2P2 grouped by GPR42-low versus GPR42-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR42→partner) and Y-score (partner→GPR42) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SPCS2P2 →	+0.113	+3.520	<.001	.006	3	2
BRCA	MIR6853 →	+0.242	+8.057	<.001	.005	3	1
BRCA	H2AB2 →	+0.089	+8.057	<.001	.005	3	1
BRCA	OR2AL1P →	+0.105	+7.878	<.001	<.001	3	1
BRCA	LINGO1-AS2 →	+0.107	+5.347	.003	.006	3	1
BRCA	RBM22P1 →	+0.059	+5.646	.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 94 associations by consensus.

SPCS2P2 by GPR42 expression — UCEC

Explore this box plot interactively →