GPR176

Across TCGA patient cohorts, GPR176 mutation is significantly associated with the RNA expression of many other genes, with 2,271 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR176-associated genes across cancer lineages are C16orf95, TMEM126B, and SLC25A30. Each is linked with GPR176 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR176-to-partner and partner-to-GPR176 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C16orf95 grouped by GPR176-low versus GPR176-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR176→partner) and Y-score (partner→GPR176) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C16orf95 →	+0.363	+3.595	<.001	.001	3	2
UCEC	TMEM126B →	+0.450	+3.332	.007	.005	3	2
UCEC	SLC25A30 →	+0.565	+3.364	.001	.004	3	2
LUAD	RN7SL163P →	+0.246	+4.132	<.001	.004	3	2
LUAD	MIR6807 →	+0.645	+4.658	<.001	.001	3	2
UCEC	CUEDC1 →	+0.740	+2.949	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,271 associations by consensus.

C16orf95 by GPR176 expression — UCEC

Explore this box plot interactively →