GPR176

Across TCGA pan-cancer cohorts, GPR176 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of GPR176’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where GPR176 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GPR176 is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

HNSC, KIRC, and COAD are the cancer types where GPR176 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GPR176 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+3.460	<.001	12	view →
KIRC	Female	All	+1.417	<.001	11	view →
COAD	All	All	+0.588	<.001	10	view →
LIHC	All	II,III,IV	+0.802	<.001	7	view →
STAD	Male	II,III,IV	+1.080	<.001	6	view →
KICH	Female	All	−1.565	<.001	5	view →
LUAD	Male	All	+0.761	.007	5	view →
CHOL	All	All	+2.246	.002	2	view →
ESCA	All	All	+1.326	.008	2	view →
UCEC	All	All	−0.874	.005	2	view →
THCA	Female	III,IV	+0.482	.008	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

GPR176–HNSC

Open the HNSC breakdown →