GPR137C

Across TCGA patient cohorts, GPR137C mutation is significantly associated with the RNA expression of many other genes, with 756 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR137C-associated genes across cancer lineages are MIR6766, MIR3661, and CRTC1P1. Each is linked with GPR137C in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR137C-to-partner and partner-to-GPR137C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6766 grouped by GPR137C-low versus GPR137C-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR137C→partner) and Y-score (partner→GPR137C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MIR6766 →	+0.397	+4.393	<.001	.008	3	2
UCEC	MIR3661 →	+0.591	+2.216	.004	.002	3	2
UCEC	CRTC1P1 →	+0.106	+2.530	<.001	.001	3	2
UCEC	NDUFA3P3 →	+0.181	+2.281	<.001	.007	3	2
COAD	RNU7-176P →	+0.537	+7.741	<.001	.009	3	1
COAD	PPP1R26P4 →	+0.014	+7.741	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 756 associations by consensus.

MIR6766 by GPR137C expression — LUSC

Explore this box plot interactively →