Q-omics provides the consensus-scored CRTC1P1 profile across patient tissues and cancer cell-line models. CRTC1P1 expression is associated with patient survival in 12 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, CRTC1P1 is differentially expressed in 5, with the highest sampling consensus in UCEC. Additionally, CRTC1P1 RNA expression shows 6,276 significant pathway-activity associations, with the highest sampling consensus in STAD. Together, these results highlight KIRC, UCEC, and STAD as cancer lineages where CRTC1P1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for CRTC1P1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes CRTC1P1 survival associations across molecular data types. CRTC1P1 RNA expression shows survival associations in the most cancer types (12). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible CRTC1P1 RNA expression–survival associations across cancer types. High CRTC1P1 expression shows unfavorable associations in KIRC, ESCA, LUSC, KICH, ACC and SARC. The KIRC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .010). Together, the overview and detailed table identify KIRC as the clearest survival context for CRTC1P1 RNA expression.
This table summarizes CRTC1P1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 5. The strongest signals are observed in HNSC for RNA.
This table ranks reproducible tumor–normal expression differences for CRTC1P1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. CRTC1P1 shows higher tumor expression in UCEC, COAD, HNSC, STAD and LIHC. The UCEC box plot shows higher CRTC1P1 RNA expression in tumor versus normal tissue (log2 FC = +0.078, t-test p = .012).
This table shows molecular features associated with CRTC1P1 in patient tissues and cancer cell lines. In patient samples, CRTC1P1 shows the broadest associations at the RNA and protein expression levels, with STAD recurring as the lineage with the largest associated feature set.
