GPR137C

Across TCGA pan-cancer cohorts, GPR137C RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated GPR137C data layer compared with 3 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher GPR137C RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated GPR137C expression acts as an unfavorable survival marker, although some lineages such as KIRC and GBM show a favorable association.

ACC, UVM, and MESO are the cancer types where GPR137C RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.206	0.718	<.001	129	view →
UVM	DFS	Tertile	II,III,IV	0.547	0.950	.003	92	view →
MESO	OS	Tertile	All	0.454	0.741	<.001	86	view →
KICH	OS	Quartile	All	0.621	1.000	.004	70	view →
KIRC	OS	Median	All	0.720	0.556	<.001	57	view →
LIHC	DFS	Tertile	All	0.455	0.614	.003	36	view →
GBM	OS	Median	All	0.568	0.253	<.001	27	view →
SKCM	OS	Quartile	III,IV	0.401	0.159	.005	20	view →
PRAD	DFS	Median	All	0.698	0.873	<.001	20	view →
KIRP	OS	Quartile	All	0.845	0.959	.003	19	view →
OV	OS	Quartile	All	0.749	0.649	.019	16	view →
STAD	OS	Median	IV	0.564	0.192	.004	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

GPR137C–ACC (DFS)

Open the ACC breakdown →