GPR137C

Across TCGA pan-cancer cohorts, GPR137C RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of GPR137C’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where GPR137C RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GPR137C is over-expressed in tumor, although a few such as LUSC and READ show the opposite, repressed pattern.

HNSC, LIHC, and UCEC are the cancer types where GPR137C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GPR137C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.310	<.001	12	view →
LIHC	Female	III,IV	+0.550	<.001	8	view →
UCEC	All	II,III,IV	+1.507	<.001	6	view →
BRCA	All	III,IV	+0.774	<.001	6	view →
BLCA	All	III,IV	+0.461	.017	6	view →
THCA	Female	All	+0.335	<.001	6	view →
KIRP	All	III,IV	+0.379	.012	4	view →
STAD	All	II,III,IV	+0.339	.003	4	view →
CHOL	All	All	+0.651	.002	3	view →
KIRC	All	All	+0.227	<.001	3	view →
LUSC	All	III,IV	−0.605	.003	2	view →
READ	Female	All	−0.348	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

GPR137C–HNSC

Open the HNSC breakdown →