GMNN

Across TCGA cell cohorts, GMNN mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GMNN-associated genes across cancer lineages are PTH2R, CFAP47, and KRTAP5-3. Each is linked with GMNN in more than 1 cancer types. Because this analysis shows association rather than direction, both GMNN-to-partner and partner-to-GMNN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PTH2R grouped by GMNN-low versus GMNN-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GMNN→partner) and Y-score (partner→GMNN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PTH2R →	+1.163	+3.453	<.001	.009	3	1
LARGE_INTESTINE	CFAP47 →	+0.196	+3.453	.008	.009	3	1
LARGE_INTESTINE	KRTAP5-3 →	+0.030	+3.632	<.001	.003	3	1
LARGE_INTESTINE	PRAMEF20 →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	NEXMIF →	+0.277	+3.196	<.001	.007	3	1
LARGE_INTESTINE	ADAM7 →	+0.006	+4.345	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

PTH2R by GMNN expression — LARGE_INTESTINE

Explore this box plot interactively →