GMNN

Across TCGA pan-cancer cohorts, GMNN RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated GMNN data layer compared with 3 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher GMNN RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated GMNN expression acts as an unfavorable survival marker, although some lineages such as OV and KIRC show a favorable association.

KIRP, ACC, and MESO are the cancer types where GMNN RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Quartile	All	0.697	0.923	<.001	117	view →
ACC	DFS	Median	All	0.274	0.634	<.001	105	view →
MESO	OS	Tertile	All	0.353	0.685	<.001	99	view →
OV	OS	Quartile	III,IV	0.453	0.287	<.001	72	view →
UVM	DFS	Quartile	III,IV	0.183	0.922	<.001	46	view →
KIRC	DFS	Tertile	All	0.722	0.478	.003	46	view →
ESCA	OS	Median	III,IV	0.376	0.732	<.001	43	view →
PAAD	OS	Tertile	All	0.338	0.661	.003	40	view →
CHOL	DFS	Tertile	All	0.168	0.701	<.001	36	view →
SARC	DFS	Tertile	All	0.518	0.714	<.001	31	view →
LIHC	OS	Quartile	All	0.675	0.853	.002	28	view →
READ	OS	Tertile	All	1.000	0.345	.007	27	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

GMNN–KIRP (DFS)

Open the KIRP breakdown →