GMNN

Across TCGA pan-cancer cohorts, GMNN RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of GMNN’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where GMNN RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GMNN is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

HNSC, KICH, and LUAD are the cancer types where GMNN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GMNN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+1.628	<.001	12	view →
KICH	Female	II,III,IV	−2.635	<.001	11	view →
LUAD	Male	All	+1.417	<.001	11	view →
LIHC	Female	II,III,IV	+2.454	<.001	9	view →
LUSC	Female	All	+2.112	<.001	8	view →
STAD	All	II,III,IV	+1.170	<.001	7	view →
THCA	All	All	−0.297	<.001	7	view →
BLCA	All	All	+1.313	<.001	6	view →
UCEC	All	All	+0.870	<.001	6	view →
KIRC	All	All	−0.341	<.001	6	view →
CHOL	Female	All	+5.653	<.001	3	view →
ESCA	All	All	+1.043	.007	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

GMNN–HNSC

Open the HNSC breakdown →