Q-omics provides the consensus-scored GMDS-DT profile across patient tissues and cancer cell-line models. GMDS-DT expression is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in LUAD. Among the 18 cancer types available for tumor–normal comparison, GMDS-DT is differentially expressed in 8, with the highest sampling consensus in KICH. Additionally, GMDS-DT RNA expression shows 21,413 significant gene co-expression associations, with the highest sampling consensus in KIRP. Together, these results highlight LUAD, KICH, and KIRP as cancer lineages where GMDS-DT shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for GMDS-DT — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes GMDS-DT survival associations across molecular data types. GMDS-DT RNA expression shows survival associations in the most cancer types (22). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible GMDS-DT RNA expression–survival associations across cancer types. High GMDS-DT expression shows unfavorable associations in COAD, but favorable associations in LUAD, MESO, UCS, KIRP and PAAD. The LUAD Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify LUAD as the clearest survival context for GMDS-DT RNA expression.
This table summarizes GMDS-DT tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 8. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for GMDS-DT. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. GMDS-DT shows lower tumor expression in KICH, THCA, LUSC and UCEC and higher tumor expression in LIHC and CHOL. The KICH box plot shows higher GMDS-DT RNA expression in normal versus tumor tissue (log2 FC = −0.617, t-test p < 0.001).
This table shows molecular features associated with GMDS-DT in patient tissues and cancer cell lines. In patient samples, GMDS-DT shows the broadest associations at the RNA and protein expression levels, with KIRP recurring as the lineage with the largest associated feature set.
