GMDS-DT

Across TCGA pan-cancer cohorts, GMDS-DT RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of GMDS-DT’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where GMDS-DT RNA is repressed in tumor relative to normal tissue. In most cancer types GMDS-DT is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and LIHC are the cancer types where GMDS-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GMDS-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−0.617	<.001	10	view →
THCA	Male	III,IV	−0.561	<.001	10	view →
LIHC	Female	II,III,IV	+0.311	<.001	7	view →
LUSC	Male	III,IV	−0.557	<.001	6	view →
UCEC	All	All	−0.330	<.001	6	view →
CHOL	All	All	+0.656	<.001	5	view →
LUAD	All	All	+0.331	<.001	4	view →
PRAD	All	All	+0.283	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

GMDS-DT–KICH

Open the KICH breakdown →