GMDS-DT

Across TCGA pan-cancer cohorts, GMDS-DT RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated GMDS-DT data layer.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher GMDS-DT RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated GMDS-DT expression acts as an unfavorable survival marker, although some lineages such as LUAD and MESO show a favorable association.

LUAD, MESO, and COAD are the cancer types where GMDS-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.848	0.682	<.001	74	view →
MESO	OS	Quartile	All	0.705	0.345	<.001	72	view →
COAD	DFS	Quartile	All	0.558	0.737	.002	41	view →
UCS	DFS	Median	IV	0.909	0.416	.008	36	view →
KIRP	DFS	Median	All	0.909	0.606	.004	33	view →
PAAD	DFS	Median	II,III,IV	0.528	0.343	.009	32	view →
SKCM	DFS	Quartile	All	0.230	0.103	<.001	30	view →
READ	OS	Tertile	All	1.000	0.289	.001	28	view →
KICH	OS	Tertile	II,III,IV	0.595	1.000	.003	26	view →
BRCA	OS	Median	III,IV	0.889	0.769	.009	22	view →
KIRC	OS	Tertile	All	0.709	0.569	.004	22	view →
BLCA	OS	Tertile	All	0.805	0.670	.018	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GMDS-DT–LUAD (DFS)

Open the LUAD breakdown →