GLI1

Across TCGA patient cohorts, GLI1 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,698 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible GLI1-associated proteins across cancer lineages are OLFML1, SYNPO2, and TMEM119. Each is linked with GLI1 in more than 6 cancer types. Because this analysis shows association rather than direction, both GLI1-to-partner and partner-to-GLI1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GLI1 versus OLFML1 in CCRCC, with a Pearson correlation of 0.46.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (GLI1→partner) and Y-score (partner→GLI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	OLFML1 →	+1.195	+0.456	<.001	<.001	3	7
UCEC	SYNPO2 →	+0.788	+0.845	<.001	<.001	3	7
UCEC	TMEM119 →	+0.886	+1.074	<.001	<.001	3	7
UCEC	PGM5 →	+0.784	+0.780	<.001	<.001	3	6
LSCC	CACNA2D1 →	+0.824	+1.163	<.001	<.001	3	6
UCEC	CD248 →	+0.685	+1.301	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,698 associations by consensus.

GLI1 vs OLFML1 — CCRCC

Explore this scatter interactively →