GLI1

Across TCGA pan-cancer cohorts, GLI1 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated GLI1 data layer compared with 3 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher GLI1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated GLI1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and UCEC show a favorable association.

KIRP, BRCA, and UVM are the cancer types where GLI1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	II,III,IV	0.322	0.749	<.001	89	view →
BRCA	OS	Median	All	0.977	0.946	<.001	76	view →
UVM	DFS	Tertile	All	0.332	0.836	.001	60	view →
ACC	DFS	Tertile	All	0.220	0.690	<.001	59	view →
UCEC	DFS	Tertile	II,III,IV	0.760	0.488	.004	48	view →
THCA	DFS	Tertile	II,III,IV	0.647	0.980	.002	47	view →
LGG	OS	Tertile	All	0.436	0.684	<.001	35	view →
LUAD	DFS	Median	III,IV	0.269	0.697	<.001	35	view →
BLCA	OS	Quartile	All	0.317	0.636	<.001	22	view →
UCS	DFS	Median	III,IV	0.599	0.265	.003	20	view →
CHOL	DFS	Median	All	0.858	0.128	.002	15	view →
SKCM	OS	Median	III,IV	0.735	0.927	.002	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GLI1–KIRP (DFS)

Open the KIRP breakdown →