GLI1

Across TCGA patient cohorts, GLI1 protein abundance is significantly associated with the RNA expression of many other genes, with 1,245 significant associations in total. GBM shows the largest number of these associations.

The most reproducible GLI1-associated genes across cancer lineages are CCDC113, EEF2K, and CORO2B. Each is linked with GLI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GLI1-to-partner and partner-to-GLI1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GLI1 versus CCDC113 in PDAC, with a Pearson correlation of -0.51.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLI1→partner) and Y-score (partner→GLI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CCDC113 →	-0.523	-0.502	.004	<.001	3	1
PDAC	EEF2K →	-0.325	-0.437	.001	<.001	3	1
PDAC	CORO2B →	+0.457	+0.325	.002	.009	3	1
PDAC	ILVBL →	-0.274	-0.394	.009	.001	3	1
PDAC	KISS1R →	+0.401	+0.536	.001	.001	3	1
PDAC	SPDEF →	-1.227	-0.350	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,245 associations by consensus.

GLI1 vs CCDC113 — PDAC

Explore this scatter interactively →