GLI1

Across TCGA cell cohorts, GLI1 mutation is significantly associated with the RNA expression of many other genes, with 481 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GLI1-associated genes across cancer lineages are PRSS54, PSKH2, and VN1R2. Each is linked with GLI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GLI1-to-partner and partner-to-GLI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRSS54 grouped by GLI1-low versus GLI1-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLI1→partner) and Y-score (partner→GLI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PRSS54 →	+0.078	+4.672	<.001	.002	3	2
BREAST	PSKH2 →	+0.083	+4.421	<.001	.004	3	2
LUNG_NSCLC_LUAD	VN1R2 →	+0.042	+3.959	<.001	.001	3	2
LARGE_INTESTINE	MAGEB4 →	+0.007	+2.678	.001	.005	3	2
LUNG_SCLC	OR5B21 →	+0.044	+4.269	<.001	.005	3	1
BREAST	CLEC1B →	+0.013	+4.199	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 481 associations by consensus.

PRSS54 by GLI1 expression — BREAST

Explore this box plot interactively →