GDPD3

Across TCGA patient cohorts, GDPD3 mutation is significantly associated with the RNA expression of many other genes, with 778 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GDPD3-associated genes across cancer lineages are CYCSP49, EEF1E1-BLOC1S5, and RNU6-15P. Each is linked with GDPD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both GDPD3-to-partner and partner-to-GDPD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CYCSP49 grouped by GDPD3-low versus GDPD3-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GDPD3→partner) and Y-score (partner→GDPD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	CYCSP49 →	+0.472	+4.031	.002	.004	3	2
LUSC	EEF1E1-BLOC1S5 →	+0.113	+3.748	<.001	.008	3	2
HNSC	RNU6-15P →	+0.346	+4.372	.004	.007	3	2
UCEC	RN7SL504P →	+0.100	+3.121	<.001	.001	3	2
UCEC	TRBV8-1 →	+0.166	+2.747	.004	<.001	3	2
UCEC	RN7SL654P →	+0.115	+2.787	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 778 associations by consensus.

CYCSP49 by GDPD3 expression — LUSC

Explore this box plot interactively →