GDPD3

Across TCGA pan-cancer cohorts, GDPD3 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of GDPD3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where GDPD3 RNA is repressed in tumor relative to normal tissue. In most cancer types GDPD3 is over-expressed in tumor, although a few such as HNSC and KIRP show the opposite, repressed pattern.

HNSC, KIRP, and COAD are the cancer types where GDPD3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GDPD3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	−2.733	<.001	12	view →
KIRP	Female	II,III,IV	−2.472	<.001	11	view →
COAD	Female	All	−2.128	<.001	11	view →
BLCA	All	IV	+3.654	.001	9	view →
KICH	Female	All	−2.240	<.001	8	view →
READ	All	All	−1.447	.001	6	view →
LIHC	All	All	+0.507	<.001	6	view →
CHOL	All	All	+2.071	<.001	3	view →
KIRC	Male	All	−0.938	<.001	3	view →
PAAD	Male	All	+1.715	.034	2	view →
LUSC	Female	II,III,IV	−1.328	<.001	2	view →
PRAD	All	All	−0.487	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

GDPD3–HNSC

Open the HNSC breakdown →