TRBV8-1

Q-omics provides the consensus-scored TRBV8-1 profile across patient tissues and cancer cell-line models. TRBV8-1 expression is associated with patient survival in 5 of 34 cancer types, with the highest sampling consensus in LAML. Additionally, TRBV8-1 RNA expression shows 9,191 significant gene co-expression associations, with the highest sampling consensus in COAD. Together, these results highlight LAML, and COAD as cancer lineages where TRBV8-1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.

Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.

Survival associations

This table summarizes TRBV8-1 survival associations across molecular data types. TRBV8-1 RNA expression shows survival associations in the most cancer types (5). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.

TRBV8-1 data type	Survival analysis	Lineage consensus	Lineage of highest sampling consensus
RNA	Kaplan–Meier	5	LAML (36)	view →

This table ranks reproducible TRBV8-1 RNA expression–survival associations across cancer types. High TRBV8-1 expression shows unfavorable associations in LUSC, LUAD and THYM, but favorable associations in LAML and ESCA. The LAML Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .004). Together, the overview and detailed table identify LAML as the clearest survival context for TRBV8-1 RNA expression.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LAML	DFS	Median	All	0.700	0.440	.004	36	view →
LUSC	DFS	Tertile	All	0.228	0.722	<.001	27	view →
LUAD	OS	Tertile	All	0.222	0.788	.001	27	view →
ESCA	DFS	Tertile	II,III,IV	0.629	0.332	.049	6	view →
THYM	DFS	Tertile	II,III,IV	0.787	0.918	.026	3	view →

Pink = unfavorable, green = favorable. all 5 lineages →

TRBV8-1-LAML (DFS)

Explore this curve interactively →