TRBV8-1

Across TCGA pan-cancer cohorts, TRBV8-1 RNA is linked to patient survival in 5 of 34 cancer types, making it the most broadly survival-associated TRBV8-1 data layer.

The strongest signal is observed in acute myeloid leukemia (LAML), where higher TRBV8-1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TRBV8-1 expression acts as an unfavorable survival marker, although some lineages such as LAML and ESCA show a favorable association.

LAML, LUSC, and LUAD are the cancer types where TRBV8-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LAML	DFS	Median	All	0.700	0.440	.004	36	view →
LUSC	DFS	Tertile	All	0.228	0.722	<.001	27	view →
LUAD	OS	Tertile	All	0.222	0.788	.001	27	view →
ESCA	DFS	Tertile	II,III,IV	0.629	0.332	.049	6	view →
THYM	DFS	Tertile	II,III,IV	0.787	0.918	.026	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TRBV8-1–LAML (DFS)

Open the LAML breakdown →