GAL3ST1

Across TCGA patient cohorts, GAL3ST1 mutation is significantly associated with the RNA expression of many other genes, with 1,928 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GAL3ST1-associated genes across cancer lineages are TMEM138, AFAP1L1, and TPP1. Each is linked with GAL3ST1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GAL3ST1-to-partner and partner-to-GAL3ST1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM138 grouped by GAL3ST1-low versus GAL3ST1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GAL3ST1→partner) and Y-score (partner→GAL3ST1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	TMEM138 →	+0.495	+2.916	<.001	<.001	3	2
SKCM	AFAP1L1 →	-0.627	-2.163	.008	.003	3	2
UCEC	TPP1 →	+0.520	+1.885	<.001	.001	3	2
UCEC	GPX4 →	+0.475	+2.255	<.001	<.001	3	2
UCEC	MCRIP2 →	+0.453	+1.885	.001	.001	3	2
UCEC	DBNDD1 →	+0.485	+2.439	.008	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,928 associations by consensus.

TMEM138 by GAL3ST1 expression — SKCM

Explore this box plot interactively →