GAL3ST1

Across TCGA pan-cancer cohorts, GAL3ST1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of GAL3ST1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where GAL3ST1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GAL3ST1 is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

KIRC, KICH, and LIHC are the cancer types where GAL3ST1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GAL3ST1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	IV	+3.620	<.001	12	view →
KICH	Male	All	−2.346	<.001	10	view →
LIHC	All	II,III,IV	+1.660	<.001	7	view →
LUSC	Female	II,III,IV	−1.347	<.001	7	view →
BRCA	Female	All	−0.460	<.001	6	view →
BLCA	All	IV	−0.422	<.001	5	view →
READ	All	II,III,IV	−1.660	.025	4	view →
CHOL	All	All	+3.947	<.001	3	view →
KIRP	All	II,III,IV	+1.154	.019	2	view →
PRAD	All	All	−0.426	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

GAL3ST1–KIRC

Open the KIRC breakdown →