GADD45G

Across TCGA patient cohorts, GADD45G mutation is significantly associated with the RNA expression of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GADD45G-associated genes across cancer lineages are RNA5SP519, SAA3P, and OR10G7. Each is linked with GADD45G in more than 1 cancer types. Because this analysis shows association rather than direction, both GADD45G-to-partner and partner-to-GADD45G results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP519 grouped by GADD45G-low versus GADD45G-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GADD45G→partner) and Y-score (partner→GADD45G) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP519 →	+1.592	+5.567	<.001	<.001	3	2
COAD	SAA3P →	+0.139	+5.145	<.001	.007	3	1
UCEC	OR10G7 →	+0.095	+5.123	<.001	.004	3	1
UCEC	HSD3BP1 →	+0.114	+5.616	<.001	<.001	3	1
UCEC	RNA5SP258 →	+0.544	+5.877	<.001	.001	3	1
UCEC	RNA5SP326 →	+1.211	+4.771	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

RNA5SP519 by GADD45G expression — UCEC

Explore this box plot interactively →