GADD45G

Across TCGA pan-cancer cohorts, GADD45G RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of GADD45G’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where GADD45G RNA is repressed in tumor relative to normal tissue. In most cancer types GADD45G is over-expressed in tumor, although a few such as THCA and BLCA show the opposite, repressed pattern.

THCA, BLCA, and LIHC are the cancer types where GADD45G tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GADD45G RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−1.318	<.001	11	view →
BLCA	Male	III,IV	−1.921	<.001	8	view →
LIHC	Female	All	−1.515	<.001	8	view →
LUSC	All	II,III,IV	−1.426	<.001	8	view →
KIRP	All	II,III,IV	−1.251	<.001	7	view →
COAD	Female	All	+0.987	<.001	7	view →
KIRC	Male	II,III,IV	−0.857	<.001	7	view →
UCEC	All	II,III,IV	−1.520	<.001	6	view →
BRCA	All	III,IV	+1.360	<.001	6	view →
CHOL	Male	All	−3.910	<.001	5	view →
KICH	All	All	+1.183	.003	3	view →
HNSC	Male	All	−0.912	.019	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

GADD45G–THCA

Open the THCA breakdown →