GADD45G

Across TCGA pan-cancer cohorts, GADD45G RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated GADD45G data layer compared with 1 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher GADD45G RNA is associated with worse overall survival. In most high-consensus cancer types, elevated GADD45G expression acts as an unfavorable survival marker, although some lineages such as LIHC and SARC show a favorable association.

UVM, LIHC, and SARC are the cancer types where GADD45G RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.412	0.775	<.001	107	view →
LIHC	OS	Median	All	0.830	0.722	.001	53	view →
SARC	OS	Tertile	All	0.840	0.583	.001	28	view →
PAAD	DFS	Median	All	0.394	0.173	<.001	27	view →
UCEC	DFS	Tertile	All	0.821	0.592	.002	26	view →
LUAD	DFS	Tertile	IV	0.856	0.449	.016	20	view →
THYM	DFS	Tertile	II,III,IV	0.539	0.917	.004	18	view →
SKCM	OS	Median	All	0.423	0.279	.005	16	view →
UCS	DFS	Tertile	II,III,IV	0.697	0.310	.012	14	view →
SCLC	DFS	Median	II,III,IV	0.743	0.441	.008	12	view →
THCA	DFS	Tertile	All	0.951	0.848	.003	10	view →
LGG	OS	Tertile	All	0.583	0.405	.002	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GADD45G–UVM (OS)

Open the UVM breakdown →