FCGR2A

Across TCGA patient cohorts, FCGR2A mutation is significantly associated with the RNA expression of many other genes, with 1,290 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FCGR2A-associated genes across cancer lineages are RN7SL299P, RNA5SP65, and RNA5SP412. Each is linked with FCGR2A in more than 1 cancer types. Because this analysis shows association rather than direction, both FCGR2A-to-partner and partner-to-FCGR2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL299P grouped by FCGR2A-low versus FCGR2A-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FCGR2A→partner) and Y-score (partner→FCGR2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RN7SL299P →	+0.128	+4.884	<.001	.004	3	2
LUAD	RNA5SP65 →	+0.852	+5.473	<.001	<.001	3	2
UCEC	RNA5SP412 →	+0.649	+1.967	<.001	.005	3	2
SKCM	MIR4757 →	+0.435	+4.614	<.001	.006	3	2
SKCM	RNU1-134P →	+0.391	+4.156	<.001	.004	3	2
SKCM	RNU6-1169P →	+0.434	+4.947	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,290 associations by consensus.

RN7SL299P by FCGR2A expression — SKCM

Explore this box plot interactively →