FCGR2A

Across TCGA pan-cancer cohorts, FCGR2A RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated FCGR2A data layer compared with 6 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher FCGR2A RNA is associated with better overall survival. In most high-consensus cancer types, elevated FCGR2A expression acts as an unfavorable survival marker, although some lineages such as SKCM and CHOL show a favorable association.

SKCM, LGG, and LUSC are the cancer types where FCGR2A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.422	0.239	<.001	103	view →
LGG	OS	Median	All	0.351	0.554	<.001	54	view →
LUSC	OS	Quartile	II,III,IV	0.346	0.780	.004	41	view →
KIRP	DFS	Tertile	All	0.540	0.895	.002	37	view →
STAD	OS	Tertile	II,III,IV	0.419	0.693	.015	28	view →
ACC	OS	Tertile	III,IV	0.242	0.753	.021	16	view →
GBM	DFS	Median	All	0.153	0.253	.004	16	view →
MESO	OS	Median	All	0.295	0.468	.005	16	view →
BRCA	DFS	Tertile	II,III,IV	0.862	0.918	.009	13	view →
HNSC	OS	Tertile	All	0.572	0.812	.001	12	view →
READ	DFS	Median	IV	0.179	0.936	.010	11	view →
CHOL	DFS	Median	All	0.743	0.142	.018	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

FCGR2A–SKCM (OS)

Open the SKCM breakdown →