FBXW12

Across TCGA patient cohorts, FBXW12 RNA expression is significantly associated with the protein abundance of many other proteins, with 18,381 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible FBXW12-associated proteins across cancer lineages are DHX9, CBX8, and SEC24A. Each is linked with FBXW12 in more than 4 cancer types. Because this analysis shows association rather than direction, both FBXW12-to-partner and partner-to-FBXW12 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FBXW12 versus DHX9 in LSCC, with a Pearson correlation of 0.47.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXW12→partner) and Y-score (partner→FBXW12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DHX9 →	+0.370	+0.548	<.001	<.001	3	5
GBM	CBX8 →	+0.424	+0.461	<.001	<.001	3	5
CCRCC	SEC24A →	-0.265	-0.181	.002	.002	3	5
HNSC	TOP2B_S1552 →	+0.458	+0.538	<.001	.001	3	4
PDAC	POLR2A →	+0.204	+0.477	<.001	<.001	3	4
GBM	PSAT1 →	+0.713	+0.636	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,381 associations by consensus.

FBXW12 vs DHX9 — LSCC

Explore this scatter interactively →