FBXW12

Across TCGA pan-cancer cohorts, FBXW12 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated FBXW12 data layer compared with 5 for mutation status.

The strongest signal is observed in kidney chromophobe (KICH), where higher FBXW12 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated FBXW12 expression acts as an unfavorable survival marker, although some lineages such as ESCA and HNSC show a favorable association.

KICH, ESCA, and DLBC are the cancer types where FBXW12 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Quartile	II,III,IV	0.366	0.924	.004	55	view →
ESCA	OS	Tertile	III,IV	0.656	0.303	.013	54	view →
DLBC	DFS	Quartile	All	0.239	0.880	.001	49	view →
HNSC	OS	Median	IV	0.815	0.643	.001	49	view →
UVM	OS	Tertile	All	0.752	0.361	.001	48	view →
THCA	OS	Quartile	II,III,IV	0.914	1.000	.008	39	view →
PRAD	DFS	Tertile	All	0.720	0.890	<.001	36	view →
LAML	DFS	Quartile	All	0.656	0.371	.002	34	view →
LUAD	DFS	Median	IV	0.306	0.764	.010	26	view →
READ	OS	Tertile	All	0.829	0.520	.004	24	view →
PAAD	OS	Median	All	0.646	0.346	.005	19	view →
BLCA	OS	Median	III,IV	0.493	0.304	.003	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

FBXW12–KICH (OS)

Open the KICH breakdown →