FBXW12

Across TCGA pan-cancer cohorts, FBXW12 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of FBXW12’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where FBXW12 RNA is repressed in tumor relative to normal tissue. In most cancer types FBXW12 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and BLCA are the cancer types where FBXW12 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FBXW12 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	−0.186	<.001	12	view →
KICH	Male	All	−0.353	<.001	10	view →
BLCA	All	All	+0.241	.005	7	view →
COAD	All	II,III,IV	+0.108	<.001	6	view →
THCA	Female	All	−0.201	<.001	5	view →
BRCA	All	II,III,IV	+0.181	<.001	4	view →
LUSC	All	All	+0.121	.001	4	view →
UCEC	All	All	+0.247	.003	2	view →
CHOL	All	All	+0.243	.012	2	view →
KIRP	All	All	−0.145	.004	2	view →
READ	All	III,IV	+0.114	.030	2	view →
LUAD	Female	II,III,IV	−0.099	.013	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

FBXW12–KIRC

Open the KIRC breakdown →