FAM9B

Across TCGA patient cohorts, FAM9B mutation is significantly associated with the RNA expression of many other genes, with 3,384 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM9B-associated genes across cancer lineages are RNU6-456P, RNU6-1137P, and OR3A5P. Each is linked with FAM9B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM9B-to-partner and partner-to-FAM9B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-456P grouped by FAM9B-low versus FAM9B-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM9B→partner) and Y-score (partner→FAM9B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU6-456P →	+0.591	+6.087	<.001	.002	3	2
LUAD	RNU6-1137P →	+0.609	+5.217	<.001	.007	3	2
LUSC	OR3A5P →	+0.095	+6.309	<.001	.001	3	2
BLCA	RNU6-984P →	+0.193	+7.640	<.001	.009	3	2
SKCM	RNU6-484P →	+0.557	+3.885	<.001	.004	3	2
UCEC	RNA5SP35 →	+0.168	+2.124	.005	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,384 associations by consensus.

RNU6-456P by FAM9B expression — LUAD

Explore this box plot interactively →