FAM9B

Across TCGA pan-cancer cohorts, FAM9B RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of FAM9B’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where FAM9B RNA is repressed in tumor relative to normal tissue. In most cancer types FAM9B is over-expressed in tumor, although a few such as BLCA and KICH show the opposite, repressed pattern.

BLCA, KICH, and THCA are the cancer types where FAM9B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM9B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	All	−0.017	.004	7	view →
KICH	All	All	−0.028	.002	5	view →
THCA	Male	All	+0.015	.016	4	view →
CHOL	All	All	−0.557	<.001	2	view →
UCEC	All	All	−0.368	.001	2	view →
PRAD	All	All	−0.137	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

FAM9B–BLCA

Open the BLCA breakdown →