FAM9B

Across TCGA pan-cancer cohorts, FAM9B RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated FAM9B data layer compared with 3 for mutation status.

The strongest signal is observed in mesothelioma (MESO), where higher FAM9B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated FAM9B expression acts as an unfavorable survival marker, although some lineages such as UCS and SCLC show a favorable association.

MESO, ACC, and UCS are the cancer types where FAM9B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	II,III,IV	0.284	0.479	.005	79	view →
ACC	OS	Tertile	All	0.270	0.812	<.001	54	view →
UCS	DFS	Tertile	II,III,IV	0.573	0.136	.005	50	view →
LGG	DFS	Tertile	All	0.630	0.819	<.001	44	view →
LUAD	DFS	Median	IV	0.406	0.817	.007	37	view →
STAD	OS	Tertile	II,III,IV	0.506	0.797	.001	32	view →
SCLC	OS	Median	IV	0.772	0.201	.024	30	view →
BRCA	DFS	Tertile	II,III,IV	0.840	0.903	.003	26	view →
BLCA	OS	Median	All	0.526	0.250	.019	20	view →
KIRC	DFS	Tertile	All	0.407	0.692	.005	15	view →
SKCM	OS	Median	All	0.907	0.837	.004	14	view →
READ	OS	Tertile	All	0.748	0.931	.006	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

FAM9B–MESO (OS)

Open the MESO breakdown →