family with sequence similarity 86, member A pseudogeneGenealiases: []
Q-omics provides the consensus-scored FAM86EP profile across patient tissues and cancer cell-line models. FAM86EP expression is associated with patient survival in 19 of 34 cancer types, with the highest sampling consensus in LIHC. Among the 18 cancer types available for tumor–normal comparison, FAM86EP is differentially expressed in 11, with the highest sampling consensus in KICH. Additionally, FAM86EP RNA expression shows 18,425 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight LIHC, KICH, and UVM as cancer lineages where FAM86EP shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for FAM86EP — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes FAM86EP survival associations across molecular data types. FAM86EP RNA expression shows survival associations in the most cancer types (19), followed by mutation status (2). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible FAM86EP RNA expression–survival associations across cancer types. High FAM86EP expression shows unfavorable associations in LIHC, KICH, LGG, LUAD and DLBC, but favorable associations in READ. The LIHC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify LIHC as the clearest survival context for FAM86EP RNA expression.
This table summarizes FAM86EP tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11. The strongest signals are observed in KICH for RNA.
This table ranks reproducible tumor–normal expression differences for FAM86EP. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. FAM86EP shows lower tumor expression in KICH and higher tumor expression in LIHC, LUAD, KIRP, COAD and STAD. The KICH box plot shows higher FAM86EP RNA expression in normal versus tumor tissue (log2 FC = −1.244, t-test p < 0.001).
This table shows molecular features associated with FAM86EP in patient tissues and cancer cell lines. In patient samples, FAM86EP shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set.
