FAM86EP

Across TCGA patient cohorts, FAM86EP mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM86EP-associated genes across cancer lineages are Cyclin-E2, EGFR_pY1068, and EGFR_pY1173. Each is linked with FAM86EP in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM86EP-to-partner and partner-to-FAM86EP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by FAM86EP-low versus FAM86EP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM86EP→partner) and Y-score (partner→FAM86EP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-E2 →	+0.165	+1.874	.005	.049	3	2
UCEC	EGFR_pY1068 →	-0.279	-1.678	.001	.021	3	1
UCEC	EGFR_pY1173 →	+0.073	+1.689	.009	.007	3	1
UCEC	eIF4G →	+0.220	+1.807	.044	.025	3	1
UCEC	FASN →	+0.402	+2.115	.003	.017	3	1
UCEC	FoxM1 →	+0.193	+1.362	.034	.037	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

Cyclin-E2 by FAM86EP expression — UCEC

Explore this box plot interactively →