FAM53A

Across TCGA patient cohorts, FAM53A mutation is significantly associated with the RNA expression of many other genes, with 100 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM53A-associated genes across cancer lineages are MIR548N, MIR5692C1, and RNA5SP413. Each is linked with FAM53A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM53A-to-partner and partner-to-FAM53A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR548N grouped by FAM53A-low versus FAM53A-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM53A→partner) and Y-score (partner→FAM53A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIR548N →	+0.584	+3.214	.001	.005	3	2
HNSC	MIR5692C1 →	+0.363	+5.578	<.001	.004	3	2
LUSC	RNA5SP413 →	+1.750	+6.081	<.001	.002	3	2
SKCM	SEPTIN7P4 →	+0.110	+4.970	<.001	.005	3	1
UCEC	NUTF2P8 →	+0.129	+3.246	.001	.008	3	1
UCEC	RN7SL248P →	+0.102	+4.137	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 100 associations by consensus.

MIR548N by FAM53A expression — COAD

Explore this box plot interactively →