FAM53A

Across TCGA pan-cancer cohorts, FAM53A RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of FAM53A’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where FAM53A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FAM53A is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

LUAD, THCA, and COAD are the cancer types where FAM53A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM53A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	III,IV	+0.592	<.001	11	view →
THCA	Male	III,IV	−1.050	<.001	10	view →
COAD	Female	II,III,IV	+0.688	<.001	10	view →
LIHC	Male	All	+0.742	<.001	8	view →
READ	All	All	+0.708	.001	5	view →
KICH	Female	II,III,IV	−0.542	<.001	5	view →
LUSC	All	All	+0.384	<.001	5	view →
STAD	Male	II,III,IV	+0.408	.003	4	view →
BRCA	All	All	+0.215	<.001	4	view →
CHOL	All	All	+0.947	.005	2	view →
BLCA	All	All	+0.325	.034	2	view →
PRAD	All	All	+0.314	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

FAM53A–LUAD

Open the LUAD breakdown →