FAM186B

Across TCGA cell cohorts, FAM186B mutation is significantly associated with the RNA expression of many other genes, with 36 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FAM186B-associated genes across cancer lineages are MAGEB5, DPPA5, and PABPN1L. Each is linked with FAM186B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM186B-to-partner and partner-to-FAM186B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB5 grouped by FAM186B-low versus FAM186B-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM186B→partner) and Y-score (partner→FAM186B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
URINARY_TRACT	DPPA5 →	+0.033	+5.087	<.001	.004	3	1
URINARY_TRACT	PABPN1L →	+0.013	+5.087	<.001	.004	3	1
LUNG_NSCLC_LUAD	TAAR8 →	+0.022	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR52N5 →	+0.071	+5.228	.006	.005	3	1
LUNG_NSCLC_LUAD	OR56B1 →	+0.034	+4.887	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

MAGEB5 by FAM186B expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →