FAM186B

Across TCGA pan-cancer cohorts, FAM186B RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated FAM186B data layer compared with 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher FAM186B RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated FAM186B expression acts as an unfavorable survival marker, although some lineages such as HNSC and SCLC show a favorable association.

HNSC, SCLC, and ACC are the cancer types where FAM186B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	II,III,IV	0.778	0.634	.002	44	view →
SCLC	DFS	Tertile	II,III,IV	0.738	0.454	.005	39	view →
ACC	DFS	Tertile	III,IV	0.651	0.153	.006	34	view →
THCA	DFS	Median	IV	0.431	0.839	.001	33	view →
LGG	OS	Tertile	All	0.409	0.651	<.001	27	view →
BLCA	DFS	Quartile	IV	0.179	0.579	.005	24	view →
KIRP	OS	Median	III,IV	0.780	0.529	.015	18	view →
COAD	DFS	Median	II,III,IV	0.536	0.732	.001	15	view →
BRCA	OS	Quartile	IV	0.972	0.366	.005	14	view →
SKCM	OS	Quartile	All	0.714	0.826	.008	14	view →
READ	OS	Quartile	III,IV	0.716	0.354	.002	14	view →
MESO	OS	Quartile	III,IV	0.962	0.446	.017	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

FAM186B–HNSC (DFS)

Open the HNSC breakdown →