FAM186B

Across TCGA pan-cancer cohorts, FAM186B RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of FAM186B’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where FAM186B RNA is repressed in tumor relative to normal tissue. In most cancer types FAM186B is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.

THCA, COAD, and KICH are the cancer types where FAM186B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM186B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.425	<.001	11	view →
COAD	Female	II,III,IV	+0.296	<.001	7	view →
KICH	All	II,III,IV	+0.381	<.001	6	view →
BRCA	Female	All	−0.114	.024	6	view →
LUSC	All	All	+0.248	<.001	5	view →
LUAD	All	All	+0.190	.001	4	view →
READ	Female	All	+0.306	<.001	3	view →
STAD	All	II,III,IV	+0.185	.014	3	view →
HNSC	All	All	+0.093	.007	3	view →
LIHC	Male	All	+0.158	.010	2	view →
KIRP	All	All	+0.146	.027	2	view →
CHOL	All	All	+0.268	.021	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

FAM186B–THCA

Open the THCA breakdown →